Seleucus at this time reigned over the nations which were beyond Euphrates, and belonged to the bodies of the two first Beasts; but after six years he conquered Antigonus, and thereby became possessed of one of the four kingdoms. For Cassander being afraid of the power of Antigonus, combined with Lysimachus, Ptolemy and Seleucus, against him: and while Lysimachus invaded the parts of Asia next the Hellespont, Ptolemy subdued Phoenicia and Coelosyria, with the sea-coasts of Asia.

Seleucus came down with a powerful army into Cappadocia, and joining the confederate forces, fought Antigonus in Phrygia and slew him, and seized his kingdom, An. Nabonass. 447. After which Seleucus built Antioch, Seleucia, Laodicea, Apamea, Berrhaea, Edessa, and other cities in Syria and Asia; and in them granted the Jews equal privileges with the Greeks.

Demetrius the son of Antigonus retained but a small part of his father’s dominions, and at length lost Cyprus to Ptolemy; but afterwards killing Alexander, the son and successor of Cassander king of Macedon, he seized his kingdom, An. Nabonass. 454. Sometime after, preparing a very great army to recover his father’s dominions in Asia; Seleucus, Ptolemy, Lysimachus and Pyrrhus king of Epirus, combined against him; and Pyrrhus invading Macedon, corrupted the army of Demetrius, put him to flight, seized his kingdom, and shared it with Lysimachus. After seven months, Lysimachus beating Pyrrhus, took Macedon from him, and held it five years and a half, uniting the kingdoms of Macedon and Thrace. Lysimachus in his wars with Antigonus and Demetrius, had taken from them Caria, Lydia, and Phrygia; and had a treasure in Pergamus, a castle on the top of a conical hill in Phrygia, by the river Caicus, the custody of which he had committed to one Philataerus, who was at first faithful to him, but in the last year of his reign revolted. For Lysimachus, having at the instigation of his wife Arsinoe, slain first his own son Agathocles, and then several that lamented him; the wife of Agathocles fled with her children and brothers, and some others of their friends, and solicited Seleucus to make war upon Lysimachus; whereupon Philataerus also, who grieved at the death of Agathocles, and was accused thereof by Arsinoe, took up arms, and sided with Seleucus. On this occasion Seleucus and Lysimachus met and fought in Phrygia; and Lysimachus being slain in the battle, lost his kingdom to Seleucus, An. Nabonass. 465. Thus the Empire of the Greeks, which at first brake into four kingdoms, became now reduced into two notable ones, henceforward called by Daniel the kings of the South and North. For Ptolemy now reigned over Egypt, Lybia, Ethiopia, Arabia, Phoenicia, Coelosyria, and Cyprus; and Seleucus, having united three of the four kingdoms, had a dominion scarce inferior to that of the Persian Empire, conquered by Alexander the great. All which is thus represented by Daniel: And the king of the South [Ptolemy] shall be strong, and one of his Princes [Seleucus, one of Alexander’s Princes] shall be strong above him, and have dominion; his dominion shall be a great dominion.