2 Maccabees demonstrates several points of doctrinal interpretation deriving from Pharisaic Judaism, and also found in Catholic and Eastern Orthodox theology.

Doctrinal issues that are raised in 2 Maccabees include:

Prayer for the dead and sacrificial offerings, both to free the dead from sin
Merits of the martyrs
Intercession of the saints (15:11–17) (at least as seen from a Christian viewpoint); the New American Bible comments on verse 14 “Jeremiah’s prayer in heaven has been taken in the Roman Catholic tradition as a biblical witness to the intercession of the saints”
Resurrection of the dead
Specific mention of creation ex nihilo (II Maccabees 7:28)